Description

Canakinumab is a high-purity, recombinant human monoclonal antibody specifically designed to target and neutralize interleukin-1β (IL-1β). This product is essential for advanced pharmaceutical research and development, particularly in the field of immunology and inflammatory diseases. It is a critical raw material for researchers and manufacturers developing biosimilars, novel biologic therapies, and diagnostic assays. The compound is supplied under stringent quality controls to ensure batch-to-batch consistency for reliable experimental and production outcomes.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of biologic drugs targeting IL-1β mediated pathways.
• Biosimilar Development as a reference standard for analytical characterization and comparability studies.
• Preclinical and Clinical Research to investigate the role of IL-1β in autoimmune, cardiovascular, and oncological diseases.
• Diagnostic Reagent Manufacturing for use in ELISA kits and other immunoassays detecting IL-1β activity.
• Cell Culture and Biochemical Research as a specific inhibitor to study IL-1β signaling mechanisms in vitro.
• Quality Control Testing in pharmaceutical production, serving as a system suitability standard for potency assays.

Basic Information

Product Name	Canakinumab
CAS No.	914613-48-2
Molecular Formula	Contact for details
Molecular Weight	Approx. 145 kDa
Synonyms	ACZ885; Ilaris®; Anti-IL-1β Monoclonal Antibody; Recombinant Human Anti-Interleukin-1 Beta Antibody; CANA; Immunoglobulin G1, anti-(human interleukin 1β) (human monoclonal ACZ885 γ1-chain), disulfide with human monoclonal ACZ885 κ-chain, dimer
EINECS	Contact for details

Quality Control

Our Canakinumab is manufactured and tested under a quality management system to ensure it meets the exacting standards required for pharmaceutical development. Each batch is characterized for identity, purity, potency, and safety through a comprehensive battery of analytical tests. Certificates of Analysis (COA) documenting purity by SEC-HPLC, biological activity, endotoxin levels, and sterility are available upon request. We support compliance with ICH Q6B guidelines for biotechnological products.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -70°C. Avoid repeated freeze-thaw cycles. Under these conditions, the product remains stable for the duration indicated on the certificate. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (SEC-HPLC / MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0% (Monomer)
Protein Content (UV Absorption)	90% - 110% of label claim
Biological Activity (Cell-Based Assay)	90% - 125% of reference
Endotoxin	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.