Description

Terlipressin Acetate is a synthetic vasopressin analog, chemically modified to provide a longer duration of action. This compound is a critical active pharmaceutical ingredient (API) valued for its potent vasoconstrictive and antidiuretic properties. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for conditions such as hepatorenal syndrome and esophageal variceal bleeding.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for the treatment of bleeding esophageal varices.
• Hepatorenal Syndrome Therapy: A key component in therapeutic agents used to manage type 1 hepatorenal syndrome, improving renal function in patients with advanced cirrhosis.
• Vasoconstrictor Research: Used in preclinical and clinical research to study vasopressin receptor (V1) activity and hemodynamic effects.
• Reference Standard: Serves as a high-purity chemical reference standard in analytical laboratories for quality control and method development.
• Peptide Synthesis Intermediate: Acts as a key building block in the further synthesis of more complex peptide-based therapeutics.

Basic Information

Product Name	Terlipressin Acetate
CAS No.	914453-96-6
Molecular Formula	C52H74N16O15 • (C2H4O2)x
Molecular Weight	1227.4 g/mol (free base)
Synonyms	Glypressin; Nα-Glycyl-glycyl-glycyl-[8-lysine]vasopressin acetate; Triglycyl-lysine-vasopressin acetate; Terlipressin; Remestyp; Haemopressin; (Gly)3-LVP acetate
EINECS	Contact for details

Quality Control

Our Terlipressin Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, peptide content determination, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with cGMP and relevant pharmacopeial guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Peptide Content	≥ 80.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	5.0% - 12.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.