Description

L-Adrenaline Bitartrate is the bitartrate salt form of the naturally occurring catecholamine hormone and neurotransmitter, epinephrine. This high-purity active pharmaceutical ingredient (API) is critical for its potent vasoconstrictive, bronchodilatory, and cardiac stimulant properties. It is an essential raw material for the formulation of emergency medications, particularly in injectable solutions for the treatment of severe allergic reactions (anaphylaxis), cardiac arrest, and asthma.

Application

• Pharmaceutical API: Primary use as the active ingredient in emergency injectable formulations (e.g., EpiPen®-type auto-injectors) for anaphylaxis.
• Cardiac Resuscitation: Formulation of solutions used in advanced cardiac life support (ACLS) to manage cardiac arrest and severe bradycardia.
• Ophthalmic Solutions: Used in eye drops as a vasoconstrictor and mydriatic (pupil dilator) for surgical procedures and glaucoma treatment.
• Local Anesthetics: Added to local anesthetic solutions (e.g., lidocaine with epinephrine) to prolong anesthetic effect and reduce systemic absorption.
• Research & Development: A key reference standard and reagent in biochemical, pharmacological, and cardiovascular research.
• Veterinary Medicine: Employed in emergency veterinary care for similar indications as in human medicine.

Basic Information

Product Name	L-Adrenaline Bitartrate
CAS No.	16536-89-3
Molecular Formula	C9H13NO3 • C4H6O6
Molecular Weight	333.30 g/mol
Synonyms	(-)-Epinephrine Bitartrate; L-Epinephrine Bitartrate; Adrenaline Acid Tartrate; (R)-(-)-Adrenaline Bitartrate; 1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol bitartrate; Levorenin Bitartrate; 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol (2R,3R)-2,3-dihydroxybutanedioate (1:1); Adrenaline Hydrogen Tartrate
EINECS	240-629-6

Quality Control

Our L-Adrenaline Bitartrate is manufactured under strict quality management systems. It is typically tested to meet or exceed relevant pharmacopoeial standards such as USP, EP, and BP. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure consistency and regulatory compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, the product should be handled under an inert atmosphere for long-term storage of bulk material. Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Specific Rotation	-50.0° to -53.5° (c = 2 in water)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5%; Total impurities: ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.