Description

Dobutamine Hydrochloride CAS NO 49745-95-1 is a synthetic catecholamine and a potent, selective β-1 adrenergic receptor agonist. This high-purity active pharmaceutical ingredient (API) is critical for its positive inotropic effects, making it a cornerstone in acute cardiac care. It is primarily required by pharmaceutical manufacturers and research institutions for the formulation of injectable solutions used in hospital and clinical settings.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable formulations for the short-term treatment of cardiac decompensation.
• Hospital/Clinical Use: Formulated into solutions for intravenous administration to increase cardiac output in patients with heart failure, particularly during or after cardiac surgery.
• Cardiac Stress Testing: Used as a pharmacological stress agent in diagnostic procedures to assess coronary artery disease when exercise is not feasible.
• Veterinary Medicine: Application in critical care for animals experiencing acute heart failure or shock.
• Biochemical Research: Used as a standard or tool compound in cardiovascular and adrenergic receptor pharmacology studies.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in pharmaceutical labs.

Basic Information

Product Name	Dobutamine Hydrochloride
CAS No.	49745-95-1
Molecular Formula	C18H23NO3 • HCl
Molecular Weight	337.84 g/mol
Synonyms	Dobutamine HCl; (±)-Dobutamine Hydrochloride; 4-[2-[[1-Methyl-3-(4-hydroxyphenyl)propyl]amino]ethyl]pyrocatechol Hydrochloride; (RS)-Dobutamine Hydrochloride; DL-Dobutamine Hydrochloride; Dobutrex; Inotrex; EINECS 256-430-5
EINECS	256-430-5

Quality Control

Our Dobutamine Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to meet stringent specifications for pharmaceutical-grade APIs, including identity, purity, and impurity profiles. A Certificate of Analysis (COA) is provided with each batch, detailing results from tests such as HPLC assay, related substances, residual solvents, and microbiological examination. We support compliance with major pharmacopoeial standards (e.g., USP, EP) and cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in its original packaging to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Microbial Enumeration	Complies with Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.