Description

(+)-Bamethan CAS NO 111051-31-1 is the dextrorotatory enantiomer of the vasodilator agent Bamethan. This specific stereoisomer is of significant interest in pharmaceutical research and development due to its distinct biological activity profile compared to its racemic mixture or the opposite enantiomer. It is primarily utilized as a high-purity reference standard and a critical intermediate in the synthesis of novel, stereoselective adrenergic agents. Researchers and manufacturers in the pharmaceutical and fine chemical sectors require this compound for advanced pharmacological studies, process development, and quality control of chiral drug substances.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control testing of Bamethan and related compounds in compliance with regulatory guidelines (e.g., ICH, FDA).
• Chiral Intermediate: Serves as a key building block in the asymmetric synthesis of more complex, stereochemically pure drug candidates targeting cardiovascular and neurological pathways.
• Pharmacological Research: Employed in in vitro and in vivo studies to investigate the stereospecific binding, efficacy, and metabolic pathways of adrenergic receptor modulators.
• Process Chemistry & Development: Acts as a starting material or intermediate for optimizing synthetic routes, scaling up production, and ensuring the stereochemical integrity of final Active Pharmaceutical Ingredients (APIs).
• Impurity Profiling: Used to identify, quantify, and qualify stereoisomeric impurities in bulk drug substances to meet stringent purity specifications.

Basic Information

Product Name	(+)-Bamethan
CAS No.	111051-31-1
Molecular Formula	C12H19NO2
Molecular Weight	209.29 g/mol
Synonyms	(+)-Bamethan; (R)-Bamethan; Dextro-Bamethan; (R)-2-Hydroxy-N-(2-hydroxyethyl)-1-methyl-2-phenylethylamine; 1-(4-Hydroxyphenyl)-2-[(1R)-1-methyl-2-(methylamino)ethyl]amino]ethanol; Bamethan enantiomer (+); (R)-1-(4-Hydroxyphenyl)-1-hydroxy-2-(methylamino)propane
EINECS	Contact for details

Quality Control

Our (+)-Bamethan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical and chiral purity, identity, and consistency. We provide full traceability and support regulatory filings. A comprehensive Certificate of Analysis (COA) is supplied with each shipment, detailing results for assay, enantiomeric excess, related substances, residual solvents, and other critical parameters. Our quality standards align with ICH guidelines and current Good Manufacturing Practice (cGMP) principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.