Description

Fostamatinib Disodium Hexahydrate is a prodrug of the active metabolite R406, functioning as a potent and selective oral inhibitor of spleen tyrosine kinase (SYK). This compound is of significant commercial and research interest for its targeted mechanism of action in modulating immune cell signaling pathways. It is primarily required by pharmaceutical R&D departments, contract research organizations (CROs), and manufacturers engaged in the development of novel therapeutics for autoimmune disorders and hematological conditions.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API): Serves as the key raw material in the formulation of finished drug products targeting SYK-dependent pathways.
• Preclinical and Clinical Research: Used as a critical reference standard and biochemical tool in studies investigating immune thrombocytopenia (ITP), rheumatoid arthritis, and other autoimmune diseases.
• Biochemical Assay Development: Employed as a selective inhibitor to validate SYK-specific assays and high-throughput screening platforms in drug discovery.
• Mechanism of Action Studies: Utilized in cellular and in vivo models to elucidate the role of SYK in B-cell receptor and Fc receptor signaling cascades.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing campaigns for clinical trial material.

Basic Information

Product Name	Fostamatinib Disodium Hexahydrate
CAS No.	914295-16-2
Molecular Formula	C₂₉H₂₀FN₆O₉P • 2Na • 6H₂O
Molecular Weight	772.47 g/mol (Hexahydrate)
Synonyms	Fostamatinib Disodium Salt Hexahydrate; R788 Disodium Hexahydrate; (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2,3-dihydrobenzo[b][1,4]oxazin-4(4H)-yl)methyl dihydrogen phosphate disodium salt hexahydrate; R935788; Tamatinib Fosdium Hexahydrate; SYK Inhibitor R788 Disodium; Fostamatinib Hexahydrate Disodium Salt
EINECS	Contact for details

Quality Control

Our Fostamatinib Disodium Hexahydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via spectroscopic methods, to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Water Content (KF)	12.0% - 15.0% (Theoretical for Hexahydrate: ~14.0%)
Related Substances (HPLC)	Individual unknown impurity ≤0.5%; Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.