Description

2-[Methyl(tert-Butoxycarbonyl)Amino]-Piperidine is a high-purity, protected piperidine derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for the efficient and selective introduction of the N-methyl-N-Boc-piperidine moiety, a key structural feature in many active pharmaceutical ingredients. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Peptidomimetic Synthesis: Used in the construction of peptidomimetics and constrained peptide analogs where the piperidine scaffold is required.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that incorporate heterocyclic amine functionalities.
• Custom Chemical Synthesis: A versatile building block for contract research organizations (CROs) and CDMOs engaged in custom synthesis and scale-up projects.

Basic Information

Item	Detail
Product Name	2-[Methyl(tert-Butoxycarbonyl)Amino]-Piperidine
CAS No.	914224-73-0
Molecular Formula	C12H24N2O2
Molecular Weight	228.33 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)(methyl)amino]piperidine; N-Boc-N-Methyl-2-aminopiperidine; 2-(N-Boc-N-methylamino)piperidine; 2-(N-Methyl-N-Boc-amino)piperidine; tert-Butyl 2-piperidinyl(methyl)carbamate; 2-(Methyl((2-methyl-2-propanyl)oxycarbonyl)amino)piperidine; 914224-73-0; Boc-N-Me-2-AminoPiperidine
EINECS	Contact for details

Quality Control

Our 2-[Methyl(tert-Butoxycarbonyl)Amino]-Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and chiral integrity. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.