Description

3H-Imidazo[4,5-B]Pyridine-2-Methanamine (Hydrochloride)(1:2) is a high-purity, advanced pharmaceutical intermediate with a defined dihydrochloride salt form. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies for new therapeutic agents.
• API Development: Integral in the process development and scale-up of novel Active Pharmaceutical Ingredients, especially in oncology and central nervous system (CNS) research.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard in analytical method development.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects and pilot-scale production.

Basic Information

Product Name	3H-Imidazo[4,5-B]Pyridine-2-Methanamine (Hydrochloride)(1:2)
CAS No.	914087-69-7
Molecular Formula	C7H10Cl2N4
Molecular Weight	221.09 g/mol
Synonyms	2-(Aminomethyl)-3H-imidazo[4,5-b]pyridine dihydrochloride; 3H-Imidazo[4,5-b]pyridine-2-methanamine dihydrochloride; 2-(Aminomethyl)imidazo[4,5-b]pyridine dihydrochloride; Imidazo[4,5-b]pyridine-2-methanamine hydrochloride (1:2); 914087-69-7; UNII-8F4Q22K1QO
EINECS	Contact for details

Quality Control

Our 3H-Imidazo[4,5-B]Pyridine-2-Methanamine (Hydrochloride)(1:2) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.