Description

3-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is a high-value, protected heterocyclic building block essential for advanced organic synthesis. This compound is specifically designed to facilitate complex coupling reactions, enabling the efficient construction of novel molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other biologically active small molecules targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new active ingredients for crop protection and pest management.
• Material Science: Serves as a building block for creating functional organic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions like Suzuki, Stille, and Negishi couplings to form new carbon-carbon bonds.
• Medicinal Chemistry: Enables the rapid exploration of structure-activity relationships (SAR) by allowing for late-stage functionalization of the pyrrolopyridine core.
• Chemical Biology: Used in the synthesis of molecular probes and labeled compounds for studying biological pathways and target engagement.

Basic Information

Product Name	3-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	913983-25-2
Molecular Formula	C16H25IN2Si
Molecular Weight	400.38 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 3-iodo-1-[(1,1-dimethylethyl)dimethylsilyl]-; 3-Iodo-1-((tert-butyldimethylsilyl))-1H-pyrrolo[2,3-b]pyridine; 3-Iodo-1-TIPS-1H-pyrrolo[2,3-b]pyridine; 1-TIPS-3-iodo-7-azaindole; 3-Iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; TIPS-3-Iodo-7-azaindole; 913983-25-2; 3-Iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 3-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the rigorous demands of research and process chemistry. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality management system is designed to support compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.