Description

5-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is a high-value, organosilicon-protected heterocyclic building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of novel pharmaceuticals and agrochemicals, enabling precise functionalization at the pyrrolopyridine core. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Material Science: Serves as a building block for organic electronic materials and functional dyes.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings.
• Chemical Biology: Employed in the design and synthesis of molecular probes and labeled compounds for biological studies.
• Academic & Institutional Research: A valuable reagent for methodological development in synthetic organic chemistry laboratories.

Basic Information

Product Name	5-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	913983-21-8
Molecular Formula	C16H25IN2Si
Molecular Weight	400.38 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-iodo-1-[(1,1-dimethylethyl)dimethylsilyl]-; 5-Iodo-1-(tert-butyldimethylsilyl)-1H-pyrrolo[2,3-b]pyridine (common error/alternative); 5-Iodo-1-TIPS-1H-pyrrolo[2,3-b]pyridine; 5-Iodo-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; TIPS-Protected 5-Iodopyrrolopyridine; 913983-21-8; 5-Iodo-1-((triisopropylsilyl))-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed under an inert atmosphere such as nitrogen or argon to maximize shelf-life stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.