Description

3-(tert-Butyl) 4-Methyl (S)-1,2,3-Oxathiazolidine-3,4-Dicarboxylate 2,2-Dioxide is a high-purity chiral sulfamidate building block, essential for the stereoselective synthesis of complex molecules. Its value lies in providing a protected, activated nitrogen source for the efficient introduction of amine functionality in a controlled, enantiomerically pure manner. This compound is critically needed by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the asymmetric synthesis of β-amino acids, amino alcohols, and other nitrogen-containing pharmacophores in drug discovery and development.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and insecticides where specific stereochemistry is crucial for bioactivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands and organocatalysts.
• Peptidomimetics & PROTACs: Enables the construction of complex peptide analogs and proteolysis-targeting chimeras (PROTACs) for therapeutic applications.
• Material Science: Potential building block for chiral polymers and advanced functional materials with specific optical properties.
• Academic & Process Research: A valuable tool for methodological development in organic synthesis and scale-up process optimization.

Basic Information

Product Name	3-(tert-Butyl) 4-Methyl (S)-1,2,3-Oxathiazolidine-3,4-Dicarboxylate 2,2-Dioxide
CAS No.	913979-52-9
Molecular Formula	C10H17NO7S
Molecular Weight	295.31 g/mol
Synonyms	(S)-3-(tert-Butoxycarbonyl)-4-methoxycarbonyl-1,2,3-oxathiazolidine 2,2-dioxide; (S)-N-Boc-N-methoxycarbonyl sulfamidate; (S)-tert-Butyl methyl sulfamidate dicarboxylate; (S)-Boc-NSO; Chiral cyclic sulfamidate; (S)-4-Methyl 3-(tert-butyl) 1,2,3-oxathiazolidine-3,4-dicarboxylate 2,2-dioxide; (S)-Methyl N-(tert-butoxycarbonyl)sulfamate cyclic derivative
EINECS	Contact for details

Quality Control

Our 3-(tert-Butyl) 4-Methyl (S)-1,2,3-Oxathiazolidine-3,4-Dicarboxylate 2,2-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity standards for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.