Description

2-(Hydroxymethyl)Pyridine-5-Boronic Acid is a versatile boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its bifunctional nature, featuring both a boronic acid and a hydroxymethyl group on a pyridine scaffold, makes it an invaluable reagent for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor for functionalized heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a pivotal boronic acid coupling partner for creating biaryl and heterobiaryl structures central to drug discovery.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides with improved efficacy.
• Ligand and Catalyst Preparation: The pyridine and hydroxymethyl groups allow for the creation of novel chelating ligands and organocatalysts.
• Material Science & OLEDs: Acts as a precursor for electron-transport materials and emissive layers in organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Utilized in the design of molecular probes and activity-based protein profiling (ABPP) reagents.

Basic Information

Product Name	2-(Hydroxymethyl)Pyridine-5-Boronic Acid
CAS No.	913835-98-0
Molecular Formula	C6H8BNO3
Molecular Weight	152.95 g/mol
Synonyms	(5-Pyridinylboronic acid, 2-(hydroxymethyl)-); 2-(Hydroxymethyl)-5-pyridineboronic acid; 5-Borono-2-(hydroxymethyl)pyridine; 2-(Hydroxymethyl)pyridin-5-ylboronic acid; 2-Pyridinemethanol, 5-borono-; 913835-98-0
EINECS	Contact for details

Quality Control

Every batch of 2-(Hydroxymethyl)Pyridine-5-Boronic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.