Description

2-Chloro-4-Iodo-5-[(2S)-1-Methyl-2-Pyrrolidinyl]-Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a chiral pyrrolidine substituent. This compound is critical for research and development in medicinal chemistry, particularly for its role as a key building block in the synthesis of targeted bioactive molecules. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutic agents, especially within the fields of neurology and oncology.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and receptor-binding studies.
• Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and enzyme functions.

Basic Information

Product Name	2-Chloro-4-Iodo-5-[(2S)-1-Methyl-2-Pyrrolidinyl]-Pyridine
CAS No.	913264-28-5
Molecular Formula	C10H12ClIN2
Molecular Weight	322.57 g/mol
Synonyms	(S)-2-Chloro-4-iodo-5-(1-methylpyrrolidin-2-yl)pyridine; 5-[(2S)-1-Methyl-2-pyrrolidinyl]-2-chloro-4-iodopyridine; 2-Chloro-4-iodo-5-((S)-1-methylpyrrolidin-2-yl)pyridine; 913264-28-5; (S)-2-Chloro-4-iodo-5-(1-methyl-2-pyrrolidinyl)pyridine; 2-Chloro-4-iodo-5-[(2S)-1-methylpyrrolidin-2-yl]pyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Iodo-5-[(2S)-1-Methyl-2-Pyrrolidinyl]-Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.