Description

5'-Fluorospiro[Cyclopropane-1,3'-Indoline] is a high-value, fluorinated spirocyclic indoline derivative, serving as a sophisticated building block in modern synthetic chemistry. Its unique fused-ring structure, incorporating a cyclopropane moiety, makes it a critical intermediate for constructing complex molecular architectures with potential biological activity. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the spiroindoline scaffold.
• Advanced Material Precursor: Serves as a building block for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge transport materials, due to its rigid, conjugated structure.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Catalyst and Ligand Development: The structural motif can be incorporated into novel chiral ligands or organocatalysts for asymmetric synthesis.
• Academic and Contract Research: Essential for fundamental organic chemistry research and for contract research organizations (CROs) specializing in custom synthesis and library production.

Basic Information

Item	Details
Product Name	5'-Fluorospiro[Cyclopropane-1,3'-Indoline]
CAS No.	913179-36-9
Molecular Formula	C10H8FN
Molecular Weight	161.18 g/mol
Synonyms	5'-Fluoro-1'H-spiro[cyclopropane-1,3'-indole]; 5'-Fluorospiro[cyclopropane-1,3'-indoline]; 5-Fluoro-spiro[cyclopropane-1,3'-indoline]; Spiro[cyclopropane-1,3'-indoline], 5'-fluoro-; 913179-36-9; 5'-Fluoro-1'H-spiro[cyclopropane-1,3'-indoline]; 5-Fluoro-1'H-spiro[cyclopropane-1,3'-indoline]
EINECS	Contact for details

Quality Control

Every batch of 5'-Fluorospiro[Cyclopropane-1,3'-Indoline] is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for sensitive research and development applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, typically including results from HPLC, NMR, and MS analysis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.