Description

3-Iodo-2-(2,2,2-trifluoro-ethoxy)-pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, combining an iodine atom with a trifluoroethoxy side chain, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine and trifluoromethyl motifs.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to form new carbon-carbon bonds.
• Ligand and Catalyst Development: Utilized to create novel nitrogen-containing ligands for metal complexes used in catalysis.
• Fluorine Chemistry Building Block: The trifluoroethoxy group provides a source of fluorine, which is valuable for modulating the lipophilicity, metabolic stability, and bioavailability of target molecules.

Basic Information

Product Name	3-Iodo-2-(2,2,2-trifluoro-ethoxy)-pyridine
CAS No.	912761-82-1
Molecular Formula	C7H5F3INO
Molecular Weight	303.02 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)-3-iodopyridine; 3-Iodo-2-(2,2,2-trifluoroethoxy)pyridine; Pyridine, 3-iodo-2-(2,2,2-trifluoroethoxy)-; 3-Iodo-2-(trifluoroethoxy)pyridine; 2-(Trifluoroethoxy)-3-iodopyridine
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-2-(2,2,2-trifluoro-ethoxy)-pyridine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.