Description

Drozitumab CAS NO 912628-39-8 is a monoclonal antibody drug candidate developed for targeted cancer therapy. It matters as a precision medicine designed to bind to specific tumor-associated antigens, offering a potential therapeutic pathway with reduced off-target effects. This product is primarily needed by pharmaceutical R&D departments, biotechnology companies, and clinical research organizations engaged in the development of novel oncology treatments.

Application

• Oncology Research & Development: As a key investigational agent in preclinical and clinical studies for various cancers.
• Biopharmaceutical Manufacturing: Serves as a reference standard or active pharmaceutical ingredient (API) in the production of biologic drug formulations.
• Mechanism of Action Studies: Used in biochemical and cellular assays to study apoptosis induction and tumor cell signaling pathways.
• Drug Combination Therapy Research: Investigated in conjunction with chemotherapy, radiotherapy, or other immunotherapies to assess synergistic effects.
• Diagnostic Reagent Development: Potential use in the development of companion diagnostics for patient stratification.

Basic Information

Product Name	Drozitumab
CAS No.	912628-39-8
Molecular Formula	Data on request
Molecular Weight	Approx. 145 kDa (Contact for details)
Synonyms	PRO95780; Anti-DR5 Agonistic Monoclonal Antibody; Anti-TRAIL-R2 Agonistic Monoclonal Antibody; Anti-TNFRSF10B Agonistic Antibody; Drozitumab (USAN/INN); Humanized Anti-DR5 Agonistic mAb; TRAIL Receptor 2 Agonist Monoclonal Antibody
EINECS	Contact for details

Quality Control

Our Drozitumab is manufactured under stringent quality systems. Each batch undergoes comprehensive analytical testing, including purity assessment by SEC-HPLC and CE-SDS, potency evaluation in cell-based bioassays, and identity confirmation by mass spectrometry. We ensure compliance with relevant guidelines for biopharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, biological activity, endotoxin levels, and sterility is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled, low-humidity conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (Mass Spec)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0% (Monomer)
Protein Content (A280)	As per COA
Biological Activity (Cell Assay)	EC50 within specified range
Endotoxin	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.