Description

4-(1,1-Difluoro-Ethyl)-2-Nitro-Benzoic Acid Methyl Ester is a high-purity, fluorinated nitroaromatic ester building block of significant interest in advanced organic synthesis. This compound matters because its unique molecular architecture, featuring both a difluoroethyl and a nitro group, makes it a versatile precursor for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorinated motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides, where the fluorine atoms can improve activity and environmental profile.
• Material Science Research: Used in the synthesis of specialty polymers and advanced organic materials that require specific electronic or photophysical properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to custom synthesis organizations for client-specific projects requiring this precise fluorinated intermediate.

Basic Information

Product Name	4-(1,1-Difluoro-Ethyl)-2-Nitro-Benzoic Acid Methyl Ester
CAS No.	912575-27-0
Molecular Formula	C10H9F2NO4
Molecular Weight	245.18 g/mol
Synonyms	Methyl 4-(1,1-difluoroethyl)-2-nitrobenzoate; 2-Nitro-4-(1,1-difluoroethyl)benzoic Acid Methyl Ester; Benzoic acid, 4-(1,1-difluoroethyl)-2-nitro-, methyl ester; 912575-27-0; 4-(Difluoroethyl)-2-nitrobenzoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of 4-(1,1-Difluoro-Ethyl)-2-Nitro-Benzoic Acid Methyl Ester is produced and tested under a strict quality management system to ensure consistency and reliability for your critical R&D and scale-up processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our standard quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and documentation suitable for regulated industry use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to the nitro and ester functional groups, it should be stored separately from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.