Description

tert-Butyl 7-Formyl-3,4-Dihydro-1,8-Naphthyridine-1(2H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a reactive formyl group on a dihydronaphthyridine scaffold. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with potential therapeutic activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its versatile formyl functionality for further derivatization.
• Organic Synthesis Building Block: Serves as a sophisticated starting material for constructing complex heterocyclic compounds in academic and industrial R&D laboratories.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up synthesis under cGMP conditions for clinical trial material production.
• Chemical Reference Standard: Utilized as an analytical standard for quality control and method development in API manufacturing processes.

Basic Information

Product Name	tert-Butyl 7-Formyl-3,4-Dihydro-1,8-Naphthyridine-1(2H)-Carboxylate
CAS No.	912270-39-4
Molecular Formula	C15H18N2O3
Molecular Weight	274.32 g/mol
Synonyms	1,8-Naphthyridine-1(2H)-carboxylic acid, 3,4-dihydro-7-formyl-, 1,1-dimethylethyl ester; 1-Boc-7-formyl-1,2,3,4-tetrahydro-1,8-naphthyridine; tert-Butyl 7-formyl-1,2,3,4-tetrahydro-1,8-naphthyridine-1-carboxylate; 7-Formyl-1,2,3,4-tetrahydro-1,8-naphthyridine-1-carboxylic acid tert-butyl ester; 1-N-Boc-7-formyl-1,2,3,4-tetrahydro-1,8-naphthyridine; Boc-7-CHO-THN
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Formyl-3,4-Dihydro-1,8-Naphthyridine-1(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.