Description

3A,6,7,7A-Tetrahydro-4H-Isoxazolo[4,5-C]Pyridine-3,5-Dicarboxylic Acid 5-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused isoxazolo-pyridine heterocyclic structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and other specialty drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing complex heterocyclic libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• CNS Drug Discovery: Serves as a core structural element in the synthesis of potential neuroactive compounds targeting various receptors.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of candidate drugs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical development pipelines.
• Academic Research: Utilized in university and institutional labs for methodological development and biochemical research.

Basic Information

Product Name	3A,6,7,7A-Tetrahydro-4H-Isoxazolo[4,5-C]Pyridine-3,5-Dicarboxylic Acid 5-tert-Butyl Ester
CAS No.	912265-93-1
Molecular Formula	C13H18N2O5
Molecular Weight	282.29 g/mol
Synonyms	5-tert-Butyl 3-methyl 3a,6,7,7a-tetrahydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylate; 3a,6,7,7a-Tetrahydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid, 5-(1,1-dimethylethyl) ester; Isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid, 3a,6,7,7a-tetrahydro-4H-, 5-tert-butyl ester; tert-Butyl 3-methyl 3a,6,7,7a-tetrahydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support development and cGMP-compliant projects with the necessary documentation and regulatory starting material support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.