Description

2-Pyridinecarbonitrile, 3,5,6-Trifluoro-4-Hydroxy- is a high-purity fluorinated pyridine derivative, a critical advanced intermediate in modern organic synthesis. Its value lies in its unique trifluoro-hydroxy substitution pattern, which enables the construction of complex molecules with enhanced biological activity and physicochemical properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atoms improve metabolic stability and membrane permeability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of fluorinated polymers and electronic materials for specialized applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring the introduction of a fluorinated, functionalized pyridine core.

Basic Information

Product Name	2-Pyridinecarbonitrile, 3,5,6-Trifluoro-4-Hydroxy-
CAS No.	911803-97-9
Molecular Formula	C6H2F3N2O
Molecular Weight	178.09 g/mol
Synonyms	4-Hydroxy-3,5,6-trifluoropyridine-2-carbonitrile; 3,5,6-Trifluoro-4-hydroxypicolinonitrile; 3,5,6-Trifluoro-4-hydroxypyridine-2-carbonitrile; 2-Cyano-3,5,6-trifluoro-4-hydroxypyridine; 4-Hydroxy-3,5,6-trifluoro-2-cyanopyridine; Picolinonitrile, 3,5,6-trifluoro-4-hydroxy-; Trifluorohydroxypicolinonitrile
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarbonitrile, 3,5,6-Trifluoro-4-Hydroxy- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.