Description

5-T-Butoxycarbonylamino-4.4-Difluoro-Pentanoic Acid Methyl Ester is a high-purity, protected amino acid derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, fluorinated intermediate that enables the precise construction of complex molecules for pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in the creation of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated peptide analogs and protease inhibitors.
• Medicinal Chemistry Research: Used in the discovery and development of new drug candidates, especially for CNS targets.
• Peptidomimetic Synthesis: Enables the incorporation of difluoro motifs to enhance metabolic stability and binding affinity of peptide-based therapeutics.
• Process Chemistry: Serves as a standardized intermediate in the scalable production of complex molecules under GMP-like conditions.
• Chemical Biology Probes: Utilized in the creation of fluorinated probes for studying enzyme mechanisms and protein interactions.
• Agrochemical Research: Potential intermediate for developing novel fluorinated active ingredients with improved properties.

Basic Information

Product Name	5-T-Butoxycarbonylamino-4.4-Difluoro-Pentanoic Acid Methyl Ester
CAS No.	911634-77-0
Molecular Formula	C12H21F2NO4
Molecular Weight	281.30 g/mol
Synonyms	Methyl 5-((tert-Butoxycarbonyl)amino)-4,4-difluoropentanoate; Boc-4,4-difluoronorvaline-OMe; 4,4-Difluoro-5-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid methyl ester; (S)-Methyl 5-((tert-butoxycarbonyl)amino)-4,4-difluoropentanoate (if applicable); 4,4-Difluoro-N-Boc-norvaline methyl ester; Boc-Difluoronorvaline-OMe; 911634-77-0; tert-Butyl (4,4-difluoro-5-methoxy-5-oxopentyl)carbamate
EINECS	Contact for details

Quality Control

Our 5-T-Butoxycarbonylamino-4.4-Difluoro-Pentanoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity (where applicable), NMR for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to prevent degradation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (if applicable)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.