Description

2-(5-Bromo-3-Nitropyridin-2-Yl)Malonic Acid Diethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its bromo-nitropyridine and malonic ester functional groups. This compound is critical for the synthesis of complex heterocyclic molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Used in the research and development of organic electronic materials and specialty polymers.
• Chemical Synthesis: Acts as a versatile reagent for constructing complex pyridine-based heterocycles in academic and industrial research laboratories.
• Process Chemistry: Employed in route scouting and optimization for scalable manufacturing of target molecules.

Basic Information

Product Name	2-(5-Bromo-3-Nitropyridin-2-Yl)Malonic Acid Diethyl Ester
CAS No.	911434-04-3
Molecular Formula	C₁₂H₁₃BrN₂O₆
Molecular Weight	361.15 g/mol
Synonyms	Diethyl 2-(5-bromo-3-nitropyridin-2-yl)malonate; 2-(5-Bromo-3-nitro-2-pyridinyl)malonic Acid Diethyl Ester; Diethyl (5-Bromo-3-nitropyridin-2-yl)malonate; 911434-04-3; Malonic acid, 2-(5-bromo-3-nitro-2-pyridinyl)-, diethyl ester; Ethyl 2-(5-bromo-3-nitropyridin-2-yl)malonate
EINECS	Contact for details

Quality Control

Our 2-(5-Bromo-3-Nitropyridin-2-Yl)Malonic Acid Diethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.