Description

D-Gluconic Acid, 6-o-[(1,1-Dimethylethyl)Dimethylsilyl]-2,3,4-Tris-o-(Phenylmethyl)-, D-Lactone is a sophisticated, protected derivative of D-gluconic acid, specifically designed as a key synthetic intermediate in advanced organic chemistry. This compound matters for its role in enabling precise, multi-step syntheses where selective protection and deprotection of hydroxyl groups are critical. It is primarily needed by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of complex carbohydrates, nucleosides, and other bioactive molecules. The CAS number for this high-purity building block is 911380-37-5.

Application

This protected lactone serves as a versatile chiral building block in sophisticated synthetic pathways. Its primary applications include:

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly those with carbohydrate or nucleoside motifs.
• Glycochemistry Research: Used in the study and synthesis of oligosaccharides, glycoconjugates, and glycomimetics, where selective hydroxyl protection is required.
• Process Chemistry Development: Employed in route scouting and optimization for the production of high-value fine chemicals under controlled conditions.
• Chemical Biology Probes: Acts as a starting material for creating labeled or modified sugar derivatives used to study biological processes.
• Asymmetric Synthesis: Utilized as a chiral pool starting material for constructing enantiomerically pure compounds in medicinal chemistry.

Basic Information

Product Name	D-Gluconic Acid, 6-o-[(1,1-Dimethylethyl)Dimethylsilyl]-2,3,4-Tris-o-(Phenylmethyl)-, D-Lactone
CAS No.	911380-37-5
Molecular Formula	C34H44O6Si
Molecular Weight	576.80 g/mol
Synonyms	6-O-(tert-Butyldimethylsilyl)-2,3,4-tri-O-benzyl-D-glucono-1,5-lactone; 2,3,4-Tri-O-benzyl-6-O-(tert-butyldimethylsilyl)-D-glucono-1,5-lactone; D-Gluconic acid, 6-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3,4-tris-O-(phenylmethyl)-, D-lactone; 6-TBDMS-2,3,4-Tribenzyl-D-gluconolactone; Protected D-Gluconolactone derivative; TBDMS-Tribenzyl-D-glucono-1,5-lactone
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. We maintain strict controls to deliver high-purity synthetic intermediates with consistent batch-to-batch performance, supported by comprehensive analytical data including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.