Description

1’-T-Butoxycarbonyl-5-Hydroxy-Spiro[Chroman-2,4’-Piperidin]-4-One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its complex, privileged spirocyclic architecture.
• API Synthesis: Serves as a crucial building block in multi-step synthetic routes for producing target active pharmaceutical ingredients.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic pathways from laboratory to pilot and commercial scale.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial APIs for partner companies.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	1’-T-Butoxycarbonyl-5-Hydroxy-Spiro[Chroman-2,4’-Piperidin]-4-One
CAS No.	911227-79-7
Molecular Formula	C19H25NO5
Molecular Weight	347.41 g/mol
Synonyms	1'-Boc-5-Hydroxy-spiro[chroman-2,4'-piperidin]-4-one; tert-Butyl 5-hydroxy-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate; Spiro[chroman-2,4'-piperidin]-4-one, 1'-(1,1-dimethylethoxy)carbonyl-5-hydroxy-; 5-Hydroxy-1'-(tert-butoxycarbonyl)spiro[chroman-2,4'-piperidin]-4-one; 1'-BOC-5-Hydroxyspiro[chroman-2,4'-piperidin]-4-one; Boc-Protected 5-Hydroxy Spirochromane Piperidinone
EINECS	Contact for details

Quality Control

Our 1’-T-Butoxycarbonyl-5-Hydroxy-Spiro[Chroman-2,4’-Piperidin]-4-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and may be hygroscopic; therefore, containers should be kept sealed under inert atmosphere when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.