Description

tert-Butyl 6-Hydroxy-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents with targeted biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, particularly for central nervous system (CNS) and other receptor-targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting neurological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• API Development: Employed in the research and development of Active Pharmaceutical Ingredients (APIs) with spirocyclic or chroman-based cores.
• Chemical Biology Probes: Acts as a scaffold for creating molecular probes to study enzyme or receptor function in biological systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up for preclinical and clinical trials.

Basic Information

Product Name	tert-Butyl 6-Hydroxy-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate
CAS No.	911227-48-0
Molecular Formula	C18H23NO5
Molecular Weight	333.38 g/mol
Synonyms	1'-tert-Butoxycarbonyl-6-hydroxy-4-oxospiro[chroman-2,4'-piperidine]; 6-Hydroxy-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 6-hydroxy-4-oxospiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylate; BOC-6-Hydroxy-4-oxospiro(chroman-2,4'-piperidine); Spiro[chroman-2,4'-piperidine]-1'-carboxylic acid, 6-hydroxy-4-oxo-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Hydroxy-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.