Description

1H-Isoindole-1,3(2H)-Dione, 2-[(3S)-2,6-Dioxo-3-Piperidinyl]-4-Fluoro- is a high-purity fluorinated isoindole-1,3-dione derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its precise stereochemistry and functional groups, which are essential for constructing complex bioactive molecules in modern drug discovery. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of targeted therapies, particularly for oncology and immunology applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small-molecule drugs, especially proteasome inhibitors and immunomodulatory agents.
• Proteasome Inhibitor Research: Core structural component in the research and development of next-generation proteasome inhibitors for cancer treatment.
• Chemical Biology: Used as a molecular probe or scaffold in chemical biology to study protein-protein interactions and enzyme function.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing processes.
• Academic Research: Utilized in university and institutional labs for methodological studies in asymmetric synthesis and fluorine chemistry.
• Custom Synthesis: Basis for the custom synthesis of more complex, target-specific compounds for client-directed drug discovery programs.

Basic Information

Product Name	1H-Isoindole-1,3(2H)-Dione, 2-[(3S)-2,6-Dioxo-3-Piperidinyl]-4-Fluoro-
CAS No.	911109-85-8
Molecular Formula	C13H9FN2O4
Molecular Weight	276.22 g/mol
Synonyms	4-Fluoro-2-((S)-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; (3S)-3-(4-Fluoro-1,3-dioxoisoindolin-2-yl)piperidine-2,6-dione; 4-Fluoro-2-((S)-2,6-dioxopiperidin-3-yl)phthalimide; 4-Fluoro-2-((3S)-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 2-[(3S)-2,6-Dioxo-3-piperidinyl]-4-fluoro-1H-isoindole-1,3(2H)-dione; Fluorinated Thalidomide Analog Intermediate; 4-Fluoro-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (S-isomer)
EINECS	Contact for details

Quality Control

Our 1H-Isoindole-1,3(2H)-Dione, 2-[(3S)-2,6-Dioxo-3-Piperidinyl]-4-Fluoro- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC to confirm enantiomeric purity and NMR for structural verification, ensuring compliance with research and development grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.