Description

Cyclobutanecarboxylic Acid, 1-(Aminomethyl)-, Ethyl Ester is a high-purity, functionalized cyclobutane derivative that serves as a versatile and valuable building block in advanced organic synthesis. This compound is particularly significant for introducing the constrained cyclobutane scaffold and an amine-protected functional handle into complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the construction of advanced pesticide and herbicide molecules, where the cyclobutane ring can confer unique biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Peptidomimetics & Bioisosteres: The structure is valuable for designing peptide analogs and bioisosteric replacements in drug design to improve pharmacokinetic properties.
• Material Science Research: Investigated as a monomer or cross-linking agent for producing polymers with specific thermal or mechanical properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and target engagement.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 1-(Aminomethyl)-, Ethyl Ester
CAS No.	911060-83-8
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	Ethyl 1-(Aminomethyl)cyclobutanecarboxylate; 1-(Aminomethyl)cyclobutanecarboxylic Acid Ethyl Ester; 1-(Aminomethyl)cyclobutane-1-carboxylic Acid Ethyl Ester; (1-(Aminomethyl)cyclobutyl)carboxylic Acid Ethyl Ester; 1-Cyclobutanecarboxylic Acid, 1-(Aminomethyl)-, Ethyl Ester; Aminomethylcyclobutanecarboxylic Acid Ethyl Ester; Ethyl (1-(Aminomethyl)cyclobutane)carboxylate
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 1-(Aminomethyl)-, Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation [α] (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.