Description

(1E,3R,4S)-1-[(3As,4R,5R,6Ar)-5-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Hexahydro-5,5-Dimethylspiro[1,3-Dioxane-2,2(1H)-Pentalen]-4-Yl]-4-Methyl-1-Octen-6-Yn-3-Ol is a sophisticated, high-purity synthetic intermediate characterized by its complex stereochemistry and functional group array. Its value lies in its role as a critical chiral building block for the synthesis of complex natural products and novel pharmaceutical compounds, enabling precise control over molecular architecture. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-fidelity intermediates for constructing molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, particularly for complex targets like terpenoids and polyketides.
• Agrochemical Research: Used in the development of novel, stereochemically-defined active ingredients with enhanced efficacy and selectivity.
• Natural Product Synthesis: Serves as a crucial precursor in the total synthesis of complex natural products for biological evaluation and structure-activity relationship (SAR) studies.
• Asymmetric Catalysis Substrate: Employed as a test substrate or a starting material in the development and optimization of new asymmetric synthetic methodologies.
• Advanced Material Precursor: Potential use in creating chiral monomers or ligands for specialized polymers and catalysts.

Basic Information

Product Name	(1E,3R,4S)-1-[(3As,4R,5R,6Ar)-5-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Hexahydro-5,5-Dimethylspiro[1,3-Dioxane-2,2(1H)-Pentalen]-4-Yl]-4-Methyl-1-Octen-6-Yn-3-Ol
CAS No.	910916-95-9
Molecular Formula	C28H46O4Si
Molecular Weight	474.75 g/mol
Synonyms	1-[(3aS,4R,5R,6aR)-5-[(tert-Butyldimethylsilyl)oxy]hexahydro-5,5-dimethylspiro[1,3-dioxane-2,2'-pentalen]-4-yl]-4-methyl-1-octen-6-yn-3-ol; TBDMS-protected spiroacetal enyne alcohol; (1E,3R,4S)-TBDMS-O-Spiroacetal Intermediate; CAS 910916-95-9; Spiro[1,3-dioxane-2,2'-pentalene] derivative; Chiral enynol silyl ether; Advanced pharmaceutical building block.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict cGMP guidelines where applicable, ensuring batch-to-batch consistency and traceability. Every lot undergoes comprehensive analytical characterization, including HPLC for purity, chiral analysis, and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.