Description

2-(tert-Butoxycarbonylamino)Pyridine-5-Boronic Acid, Pinacol Ester is a high-purity, protected boronic acid ester building block essential for modern synthetic chemistry. This compound is a critical intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily used by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel chemical entities via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing pyridine and biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds with aryl and heteroaryl halides.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and for the parallel synthesis of novel compounds to explore structure-activity relationships (SAR).
• Agrochemical Synthesis: Employed in the research and development of new herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Material Science Research: A precursor for creating organic electronic materials, ligands for catalysts, and functional polymers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the life sciences sector.

Basic Information

Item	Detail
Product Name	2-(tert-Butoxycarbonylamino)Pyridine-5-Boronic Acid, Pinacol Ester
CAS No.	910462-31-6
Molecular Formula	C₁₆H₂₅BN₂O₄
Molecular Weight	320.19 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[(tert-butoxycarbonyl)amino]pyridine; 2-((Tert-Butoxycarbonyl)Amino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine; 2-(Boc-amino)-5-(pinacolboronato)pyridine; 2-(N-Boc-amino)-5-pyridineboronic acid pinacol ester; Boc-2-amino-5-pyridylboronic acid pinacol ester; 2-Amino-5-pyridineboronic acid pinacol ester, N-Boc protected; 910462-31-6
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonylamino)Pyridine-5-Boronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically exceeding 97% (by HPLC). Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.