Description

tert-Butyl 6-Methoxy-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and piperidine-based molecular architecture. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought after by pharmaceutical R&D laboratories, process development chemists, and fine chemical manufacturers engaged in the production of sophisticated therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates, especially those targeting neurological pathways.
• API Synthesis: Serves as a core scaffold for constructing complex molecules in the final stages of Active Pharmaceutical Ingredient manufacturing.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization within drug discovery programs.
• Process Chemistry: Employed in scale-up and route development for the commercial production of target molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	tert-Butyl 6-Methoxy-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	910442-59-0
Molecular Formula	C19H25NO4
Molecular Weight	331.41 g/mol
Synonyms	1'-Boc-6-methoxy-3-oxospiro[indene-1,4'-piperidine]; tert-Butyl 6-methoxy-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate; 6-Methoxy-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[indene-1,4'-piperidine]-1'-carboxylic acid, 6-methoxy-3-oxo-2,3-dihydro-, 1,1-dimethylethyl ester; 910442-59-0; Boc-protected 6-methoxyspirooxindole-piperidine
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 6-Methoxy-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. Our quality commitment aligns with cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.