Description

tert-Butyl 6-Fluoro-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery and process development of new therapeutic agents, particularly in central nervous system (CNS) and oncology-related fields.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique spirocyclic indane-piperidine structure.
• API Synthesis: Serves as a core scaffold for the development of potential new chemical entities (NCEs) targeting various disease pathways.
• Process Chemistry & Scale-Up: Employed in route scouting and process optimization for the commercial-scale manufacturing of target molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials.
• Biochemical Research: Potential use as a tool compound or ligand in biochemical assays and target validation studies.

Basic Information

Product Name	tert-Butyl 6-Fluoro-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
CAS No.	910442-55-6
Molecular Formula	C18H22FNO3
Molecular Weight	319.37 g/mol
Synonyms	1'-Boc-6-fluoro-3-oxospiro[indane-1,4'-piperidine]; tert-Butyl 6-fluoro-3-oxospiro[indane-1,4'-piperidine]-1'-carboxylate; 6-Fluoro-1,3-dihydrospiro[indene-1,4'-piperidin]-3-one 1'-carboxylic acid tert-butyl ester; Boc-6-fluoro-3-oxospiro[indane-1,4'-piperidine]; Spiro[indene-1,4'-piperidine]-1'-carboxylic acid, 6-fluoro-2,3-dihydro-3-oxo-, 1,1-dimethylethyl ester; 910442-55-6; AKOS006361889; FT-0776649
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Fluoro-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.