Description

2-Propenoic Acid, 2-Methyl-, 2-(2-Pyridinyldithio)Ethyl Ester is a specialized heterobifunctional crosslinking agent featuring a reactive pyridyl disulfide (PDS) group and a polymerizable methacrylate group. This compound is essential for creating stable, cleavable linkages in advanced material science and bioconjugation applications. It is a critical reagent for researchers and manufacturers in the fields of polymer chemistry, drug delivery systems, and surface functionalization who require precise, reversible covalent attachment strategies.

Application

• Bioconjugation and Drug Delivery: Used to create reversible disulfide linkages for attaching targeting ligands, drugs, or probes to polymers, nanoparticles, and proteins, enabling controlled release mechanisms.
• Polymer Functionalization: Serves as a key monomer or post-polymerization modifier for introducing thiol-reactive sites into acrylic polymers, hydrogels, and coatings.
• Surface Immobilization: Enables the covalent, yet cleavable, attachment of biomolecules (e.g., peptides, antibodies) to solid supports for biosensor and diagnostic assay development.
• Reversible Network Formation: Employed in the synthesis of smart materials and self-healing polymers where dynamic disulfide bonds can break and reform under specific conditions.
• Chromatography Media: Used to functionalize resin beads with thiol-reactive groups for affinity chromatography applications.
• Protein/Peptide Chemistry: Facilitates site-specific modification of cysteine residues in proteins and peptides for structural studies or activity modulation.

Basic Information

Product Name	2-Propenoic Acid, 2-Methyl-, 2-(2-Pyridinyldithio)Ethyl Ester
CAS No.	910128-59-5
Molecular Formula	C12H13NO2S2
Molecular Weight	267.37 g/mol
Synonyms	2-(Pyridyldithio)ethyl methacrylate; Pyridyl disulfide ethyl methacrylate; PDS-EMA; PDP-MA; 2-Methyl-2-propenoic acid 2-[(2-pyridinyldithio)ethyl] ester; 2-(2-Pyridinyldithio)ethyl methacrylate; Methacryloyloxyethyl pyridyl disulfide; MPDP
EINECS	Contact for details

Quality Control

Every batch of our 2-(Pyridyldithio)ethyl methacrylate is produced and tested under stringent quality management protocols to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (by HPLC/NMR), identity confirmation, and impurity profiles. Our commitment to supply chain reliability and documentation transparency supports critical R&D and scale-up processes in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at temperatures between 2°C and 8°C (refrigerated) to maximize stability and shelf-life. The container should be kept under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and moisture uptake. Allow the container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Pyridine-2-thione (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.