Description

Pentafluorophenyl 3-(1,3-Dioxolan-2-Yl)Thiophene-2-Carboxylate is a high-purity, specialized organic building block featuring a reactive pentafluorophenyl ester group and a protected aldehyde functionality. This compound is engineered for advanced synthetic chemistry, offering a versatile handle for constructing complex molecular architectures under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing thiophene-based drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate the thiophene heterocycle for enhanced bioactivity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Peptide & Bioconjugation Chemistry: The activated pentafluorophenyl ester group enables efficient amide bond formation and conjugation reactions under aqueous-compatible conditions.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and affinity labels for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring this specific molecular scaffold.

Basic Information

Product Name	Pentafluorophenyl 3-(1,3-Dioxolan-2-Yl)Thiophene-2-Carboxylate
CAS No.	910037-02-4
Molecular Formula	C15H9F5O4S
Molecular Weight	380.29 g/mol
Synonyms	2,3,4,5,6-Pentafluorophenyl 3-(1,3-dioxolan-2-yl)thiophene-2-carboxylate; 3-(1,3-Dioxolan-2-yl)thiophene-2-carboxylic acid pentafluorophenyl ester; Pentafluorophenyl 3-(1,3-dioxolan-2-yl)-2-thiophenecarboxylate; 2-Thiophenecarboxylic acid, 3-(1,3-dioxolan-2-yl)-, 2,3,4,5,6-pentafluorophenyl ester; PFP ester of 3-(1,3-dioxolan-2-yl)thiophene-2-carboxylic acid; Pentafluorophenyl (3-(1,3-dioxolan-2-yl)thiophen-2-yl)carboxylate
EINECS	Contact for details

Quality Control

Our production of Pentafluorophenyl 3-(1,3-Dioxolan-2-Yl)Thiophene-2-Carboxylate adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Every lot is fully characterized by NMR (1H, 13C, 19F), HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We operate under a quality management system and can support development projects requiring compliance with cGMP guidelines for non-clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.