Description

[(3R)-3-Amino-4-[(3-Hexylphenyl)Amino]-4-Oxobutyl]-Phosphonic Acid Mono(Trifluoroacetate) is a high-purity, chiral phosphonic acid derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block for the development of novel bioactive molecules, particularly in pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating targeted enzyme inhibitors and other biologically active agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially protease inhibitors.
• Biochemical Research: Used as a substrate analog or inhibitor in enzymatic studies to investigate metabolic pathways and enzyme mechanisms.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting various diseases.
• Agrochemical Development: Potential intermediate in the synthesis of novel herbicides or plant growth regulators with specific chiral activity.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for labeling and studying specific proteins or enzymes in complex biological systems.
• Peptidomimetic Synthesis: Acts as a phosphonate-based transition state analog in the creation of peptidomimetics, which are stable mimics of natural peptides.

Basic Information

Product Name	[(3R)-3-Amino-4-[(3-Hexylphenyl)Amino]-4-Oxobutyl]-Phosphonic Acid Mono(Trifluoroacetate)
CAS No.	909725-62-8
Molecular Formula	C18H28F3N2O6P
Molecular Weight	456.40 g/mol
Synonyms	(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutylphosphonic acid mono(2,2,2-trifluoroacetate); (R)-3-Amino-4-((3-hexylphenyl)amino)-4-oxobutylphosphonic acid trifluoroacetate salt; 909725-62-8; Phosphonic acid, P-[3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-, mono(2,2,2-trifluoroacetate), (3R)-; (R)-HAPA-TFA; TFA salt of (3R)-HAPA phosphonic acid.
EINECS	Contact for details

Quality Control

Our [(3R)-3-Amino-4-[(3-Hexylphenyl)Amino]-4-Oxobutyl]-Phosphonic Acid Mono(Trifluoroacetate) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Products undergo rigorous analytical testing, including chiral HPLC to confirm enantiomeric purity and NMR for structural verification. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.