Description

1-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Carbonyl)Piperidin-4-Yl)-1,3-Dihydro-2H-Benzimidazol-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating benzimidazolone and trifluoromethylpyridine moieties. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Research: Serves as a core scaffold for designing and synthesizing potent and selective kinase inhibitors for cancer therapy.
• CNS Drug Discovery: Used in the synthesis of compounds targeting neurological disorders due to the benzimidazolone pharmacophore.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying specific biological pathways and target validation.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale manufacturing of candidate drugs.
• Contract Research & Development (CRO/CDMO): Supplied to service organizations supporting global drug discovery pipelines.

Basic Information

Product Name	1-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Carbonyl)Piperidin-4-Yl)-1,3-Dihydro-2H-Benzimidazol-2-One
CAS No.	909682-74-2
Molecular Formula	C19H15F3N4O2
Molecular Weight	388.34 g/mol
Synonyms	1-(1-(6-(Trifluoromethyl)pyridine-3-carbonyl)piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one; 1-(1-(6-(Trifluoromethyl)nicotinoyl)piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one; 1-(1-(6-(Trifluoromethyl)pyridin-3-yl)carbonyl)piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one; 2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[6-(trifluoromethyl)-3-pyridinyl]carbonyl]-4-piperidinyl]-; CAS 909682-74-2
EINECS	Contact for details

Quality Control

Our 1-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Carbonyl)Piperidin-4-Yl)-1,3-Dihydro-2H-Benzimidazol-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.