Description

4-([4-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperidin-4-Yl)Piperazin-1-Yl]Carbonyl)Morpholine is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating piperazine, piperidine, and morpholine moieties. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis due to its privileged pharmacophores.
• API Development: Employed in the process development and scale-up of new active pharmaceutical ingredients targeting specific receptors or enzymes.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis projects under cGMP conditions for clinical trial material production.
• Biochemical Tool Compound: May be utilized in early-stage discovery as a probe to investigate biological pathways and target validation.

Basic Information

Product Name	4-([4-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperidin-4-Yl)Piperazin-1-Yl]Carbonyl)Morpholine
CAS No.	909670-33-3
Molecular Formula	C21H28F3N5O2
Molecular Weight	439.48 g/mol
Synonyms	4-({4-[1-({6-(Trifluoromethyl)pyridin-3-yl}methyl)piperidin-4-yl]piperazin-1-yl}carbonyl)morpholine; 4-[[4-[1-[[6-(Trifluoromethyl)-3-pyridinyl]methyl]-4-piperidinyl]-1-piperazinyl]carbonyl]morpholine; Morpholine, 4-[[4-[1-[[6-(trifluoromethyl)-3-pyridinyl]methyl]-4-piperidinyl]-1-piperazinyl]carbonyl]-; CAS 909670-33-3
EINECS	Contact for details

Quality Control

Our production of 4-([4-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperidin-4-Yl)Piperazin-1-Yl]Carbonyl)Morpholine adheres to stringent quality protocols suitable for pharmaceutical R&D and cGMP manufacturing. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.