Description

1-Isonicotinoyl-4-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperidin-4-Yl)Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure featuring piperazine and piperidine moieties. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular interactions. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities for oncology, central nervous system (CNS) disorders, and other specialized treatments.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting kinase inhibition or G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used extensively in research and development (R&D) laboratories for structure-activity relationship (SAR) studies and lead optimization programs.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the scale-up and production of clinical trial materials and commercial APIs.
• Bioconjugation & Probe Development: Its functional groups make it suitable for creating labeled probes or conjugates used in biochemical assays and diagnostic research.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-Isonicotinoyl-4-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperidin-4-Yl)Piperazine
CAS No.	909670-24-2
Molecular Formula	C22H24F3N5O
Molecular Weight	431.46 g/mol
Synonyms	4-[1-({6-(Trifluoromethyl)pyridin-3-yl}methyl)piperidin-4-yl]-1-(pyridine-4-carbonyl)piperazine; 1-(Isonicotinoyl)-4-[1-[[6-(trifluoromethyl)-3-pyridinyl]methyl]-4-piperidinyl]piperazine; 4-(1-((6-(Trifluoromethyl)pyridin-3-yl)methyl)piperidin-4-yl)-1-(pyridine-4-carbonyl)piperazine; 909670-24-2; UNII-4J7Q6Q9Q2T; 4J7Q6Q9Q2T
EINECS	Contact for details

Quality Control

Our 1-Isonicotinoyl-4-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperidin-4-Yl)Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.