Description

5-Fluoro-n-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperidin-4-Yl)Indoline-1-Carboxamide is a high-purity, advanced pharmaceutical intermediate designed for research and development in modern drug discovery. This compound is valued for its complex heterocyclic structure, which incorporates fluorine and trifluoromethyl groups known to enhance metabolic stability and binding affinity in bioactive molecules. It is primarily sought by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of novel therapeutic agents, particularly within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates targeting specific biological pathways.
• Oncology Research: Used in the development of potential kinase inhibitors and other targeted cancer therapies due to its specific molecular scaffold.
• CNS Drug Discovery: Serves as a core structure for research into treatments for neurological disorders, leveraging the piperidine and indoline motifs.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of lead compounds.
• Process Chemistry & Scale-Up: Used for developing and optimizing robust, scalable synthetic routes for active pharmaceutical ingredient (API) manufacturing.
• Contract Research & Development: Supplied to CROs and academic institutions for proprietary client projects and exploratory research.

Basic Information

Product Name	5-Fluoro-n-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperidin-4-Yl)Indoline-1-Carboxamide
CAS No.	909669-58-5
Molecular Formula	C22H22F4N4O
Molecular Weight	426.43 g/mol
Synonyms	5-Fluoro-N-(1-{[6-(trifluoromethyl)pyridin-3-yl]methyl}piperidin-4-yl)-2,3-dihydro-1H-indole-1-carboxamide; 1H-Indole-1-carboxamide, 5-fluoro-N-(1-((6-(trifluoromethyl)-3-pyridinyl)methyl)-4-piperidinyl)-2,3-dihydro-; 909669-58-5; 5-Fluoro-N-(1-((6-(trifluoromethyl)pyridin-3-yl)methyl)piperidin-4-yl)indoline-1-carboxamide
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-n-(1-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperidin-4-Yl)Indoline-1-Carboxamide is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity consistent with cGMP guidelines for advanced intermediates. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with each shipment to ensure traceability and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.