Description

1-{1-[2-(Trifluoromethyl)-1,6-Naphthyridin-5-Yl]Piperidin-4-Yl}Methanamine is a high-value, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting challenging disease pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its unique naphthyridine-piperidine scaffold.
• Protease Inhibitor Development: Serves as a core structural motif in the research of enzyme inhibitors, leveraging the trifluoromethyl group for enhanced binding affinity and metabolic stability.
• Ligand Synthesis for Drug Discovery: Employed in creating high-affinity ligands for various biological targets in preclinical drug discovery programs.
• Fine Chemical Synthesis: Used in custom synthesis and contract manufacturing for producing specialized, high-purity compounds for clinical trials.

Basic Information

Product Name	1-{1-[2-(Trifluoromethyl)-1,6-Naphthyridin-5-Yl]Piperidin-4-Yl}Methanamine
CAS No.	909644-98-0
Molecular Formula	C15H17F3N4
Molecular Weight	310.32 g/mol
Synonyms	1-{1-[2-(Trifluoromethyl)-1,6-naphthyridin-5-yl]piperidin-4-yl}methanamine; 1-(1-(2-(Trifluoromethyl)-1,6-naphthyridin-5-yl)piperidin-4-yl)methanamine; 5-(4-(Aminomethyl)piperidin-1-yl)-2-(trifluoromethyl)-1,6-naphthyridine; 1,6-Naphthyridine, 5-[4-(aminomethyl)-1-piperidinyl]-2-(trifluoromethyl)-; 909644-98-0; (1,6-Naphthyridine derivative)
EINECS	Contact for details

Quality Control

Our 1-{1-[2-(Trifluoromethyl)-1,6-Naphthyridin-5-Yl]Piperidin-4-Yl}Methanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.