Description

(R)-6-Oxaspiro[2.5]Octane-1-Carboxylic Acid is a high-value, chiral spirocyclic building block of significant interest in advanced organic synthesis. Its unique constrained spirocyclic structure and carboxylic acid functionality make it a critical intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced, stereospecific pesticides and herbicides where the specific spatial orientation of the molecule is crucial for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic and Industrial R&D: A valuable tool for methodological studies in organic chemistry and for exploring new chemical spaces in discovery research.

Basic Information

Product Name	(R)-6-Oxaspiro[2.5]Octane-1-Carboxylic Acid
CAS No.	909406-69-5
Molecular Formula	C8H12O3
Molecular Weight	156.18 g/mol
Synonyms	(R)-1-Oxa-7-azaspiro[2.5]octane-7-carboxylic acid (alternative numbering); (6R)-6-Oxaspiro[2.5]octane-1-carboxylic acid; (R)-Oxetane-spiro-cyclopropane-carboxylic acid; (R)-Spiro[oxetane-2,1'-cyclopropane]-1-carboxylic acid; (R)-Spirocyclic oxetane carboxylic acid; (R)-OCOA; (R)-6-Oxaspiro[2.5]octan-1-oic acid
EINECS	Contact for details

Quality Control

Our (R)-6-Oxaspiro[2.5]Octane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.