Description

Carbamic Acid, [2-Fluoro-6-[(Trimethylsilyl)Ethynyl]Phenyl]-, 1,1-Dimethylethyl Ester is a specialized, high-purity organic building block featuring a unique combination of a protected carbamate group, a fluorine substituent, and a silyl-protected alkyne moiety. This compound is of significant value in advanced pharmaceutical research and development, particularly in medicinal chemistry and drug discovery. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active compounds and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting neurological disorders and oncology.
• Medicinal Chemistry: Used for structure-activity relationship (SAR) studies and lead optimization due to its fluorine atom and versatile reactive handles.
• Peptidomimetic Synthesis: Serves as a protected amino acid derivative for constructing peptide-like molecules with enhanced metabolic stability.
• Agrochemical Research: Employed in the development of new pesticides and herbicides, leveraging its unique aromatic fluorine and alkyne functionality.
• Material Science Precursor: Potential use in creating functionalized polymers or surface coatings via the reactive alkyne group.
• Cross-Coupling Reactions: The trimethylsilyl-protected ethynyl group allows for selective deprotection and subsequent Sonogashira or other metal-catalyzed couplings.

Basic Information

Product Name	Carbamic Acid, [2-Fluoro-6-[(Trimethylsilyl)Ethynyl]Phenyl]-, 1,1-Dimethylethyl Ester
CAS No.	908600-89-5
Molecular Formula	C₁₆H₂₂FNO₂Si
Molecular Weight	307.44 g/mol
Synonyms	tert-Butyl N-[2-fluoro-6-[(trimethylsilyl)ethynyl]phenyl]carbamate; 2-Fluoro-6-((trimethylsilyl)ethynyl)phenylcarbamic Acid tert-Butyl Ester; N-Boc-2-fluoro-6-((trimethylsilyl)ethynyl)aniline; (2-Fluoro-6-((trimethylsilyl)ethynyl)phenyl)carbamic Acid tert-Butyl Ester; tert-Butyl (2-fluoro-6-((trimethylsilyl)ethynyl)phenyl)carbamate; Boc-2-F-6-TMS-Aniline; 908600-89-5; Boc-Protected 2-Fluoro-6-ethynylaniline TMS Ether
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [2-Fluoro-6-[(Trimethylsilyl)Ethynyl]Phenyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with research and cGMP standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.