Description

1H-Indole, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]- is a high-value, organosilicon-protected indole derivative, specifically functionalized with a fluorine atom at the 4-position. This compound is critically important as a versatile and protected synthetic intermediate in advanced organic and medicinal chemistry, enabling the construction of complex molecules with precise regiocontrol. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in developing novel, fluorinated pesticides and herbicides with enhanced biological activity and stability.
• Material Science Precursor: Serves as a monomer or functional unit in the development of specialty polymers and organic electronic materials.
• Chemical Synthesis: Protected intermediate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and other metal-mediated transformations.
• Fluorine Chemistry Studies: A valuable substrate for investigating the effects of fluorine substitution on indole reactivity and physicochemical properties.
• Academic & Contract Research: Essential reagent for university laboratories and CROs (Contract Research Organizations) exploring new synthetic methodologies.

Basic Information

Product Name	1H-Indole, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	908600-85-1
Molecular Formula	C17H26FNSi
Molecular Weight	291.48 g/mol
Synonyms	4-Fluoro-1-(triisopropylsilyl)-1H-indole; 1-(Triisopropylsilyl)-4-fluoro-1H-indole; 4-Fluoro-1-triisopropylsilylindole; 1-Triisopropylsilyl-4-fluoroindole; TIPS-4-fluoroindole; 4-Fluoroindole-1-TIPS; N-Triisopropylsilyl-4-fluoroindole; 908600-85-1
EINECS	Contact for details

Quality Control

Our 1H-Indole, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for advanced intermediates and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider maintaining under an inert atmosphere (argon/nitrogen) to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.