Description

1-Boc-4-Hydroxy-Piperidine-4-Carbonitrile is a high-purity, protected piperidine derivative serving as a critical chiral building block in advanced organic synthesis. This compound is valued for its versatility in constructing complex molecular architectures, particularly in the pharmaceutical sector where it acts as a key intermediate for active pharmaceutical ingredients (APIs). It is essential for research chemists and process development scientists in pharmaceutical, agrochemical, and fine chemical industries seeking reliable, high-quality intermediates for drug discovery and process optimization.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Peptidomimetics & Bioactive Molecule Construction: Used to introduce the 4-hydroxy-4-cyanopiperidine moiety into complex molecules to modulate biological activity and pharmacokinetic properties.
• Agrochemical Synthesis: Serves as a building block for developing advanced crop protection agents and pesticides.
• Ligand & Catalyst Development: Employed in the research and development of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions.

Basic Information

Product Name	1-Boc-4-Hydroxy-Piperidine-4-Carbonitrile
CAS No.	908140-15-8
Molecular Formula	C11H18N2O3
Molecular Weight	226.27 g/mol
Synonyms	4-Cyano-4-hydroxy-1-piperidinecarboxylic acid tert-butyl ester; tert-Butyl 4-cyano-4-hydroxypiperidine-1-carboxylate; 1-Boc-4-cyano-4-hydroxypiperidine; 4-Hydroxy-4-cyanopiperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-hydroxy-4-cyanopiperidine; 4-Cyano-1-N-Boc-4-piperidinol; 4-Hydroxy-1-Boc-piperidine-4-carbonitrile; 1-Boc-4-piperidinol-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Hydroxy-Piperidine-4-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to relevant standards for pharmaceutical intermediates, supporting our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.