Description

2-Hydroxymethyl-Benzoic Acid tert-Butyl Ester is a specialized benzoic acid derivative that serves as a valuable protected intermediate in advanced organic synthesis. Its structure, featuring both a hydroxymethyl group and a tert-butyl ester, makes it a versatile building block for constructing complex molecules with precise functional group manipulation. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for introducing benzoic acid-derived pharmacophores.
• Agrochemical Synthesis: Used in the research and development of herbicides, fungicides, and insecticides where the benzoate scaffold is required.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex organic molecules, leveraging the orthogonal reactivity of the hydroxymethyl and tert-butyl ester groups.
• Material Science Research: Acts as a monomer or precursor in the development of specialty polymers and functional materials.
• Chemical Biology Probe Development: Useful for synthesizing tagged molecules or probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-Hydroxymethyl-Benzoic Acid tert-Butyl Ester
CAS No.	907948-74-7
Molecular Formula	C12H16O3
Molecular Weight	208.25 g/mol
Synonyms	2-(Hydroxymethyl)benzoic acid tert-butyl ester; tert-Butyl 2-(hydroxymethyl)benzoate; Benzoic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester; 2-Carboxybenzyl alcohol tert-butyl ester; o-(Hydroxymethyl)benzoic acid tert-butyl ester; TB-2-HMBA; 2-HMBA-tBu ester
EINECS	Contact for details

Quality Control

Our 2-Hydroxymethyl-Benzoic Acid tert-Butyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.