Description

2,3,4,5-Tetrahydro-8-Trifluoromethoxy-1H-Pyrido[4,3-B]Indole is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound matters for its critical role as a sophisticated building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within central nervous system (CNS) and neurological research. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop next-generation therapeutic candidates with enhanced efficacy and selectivity profiles.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, especially for neurological and psychiatric disorders.
• CNS Drug Discovery: Serves as a core scaffold for designing and synthesizing potential ligands for serotonin, dopamine, or other neurotransmitter receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize pharmacokinetic and pharmacodynamic properties of lead compounds.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for API manufacturing under GMP conditions.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical analysis (HPLC, LC-MS).
• Biochemical Tool Compound: Applied in vitro and in vivo studies to investigate specific biological pathways and mechanisms of action.

Basic Information

Item	Detail
Product Name	2,3,4,5-Tetrahydro-8-Trifluoromethoxy-1H-Pyrido[4,3-B]Indole
CAS No.	907566-27-2
Molecular Formula	C13H13F3N2O
Molecular Weight	270.25 g/mol
Synonyms	8-(Trifluoromethoxy)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; 1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-8-(trifluoromethoxy)-; 907566-27-2; 8-Trifluoromethoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; Tetrahydro-8-trifluoromethoxypyridoindole; TFMPI intermediate
EINECS	Contact for details

Quality Control

Our 2,3,4,5-Tetrahydro-8-Trifluoromethoxy-1H-Pyrido[4,3-B]Indole is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research and development applications. All materials are subjected to comprehensive analytical characterization, including HPLC for purity, NMR, and MS for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time matches reference standard
Identification (IR)	Spectrum conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.