Description

tert-Butyl 4-[3-Bromo-5-(Methoxycarbonyl)Pyridin-2-Yl]Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a strategically functionalized pyridine and piperazine core. This compound is of critical importance for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: The bromo and ester functional groups make it a valuable intermediate for constructing potential kinase inhibitors, a major class of oncology drugs.
• CNS Drug Synthesis: The piperazine moiety is a common pharmacophore in neurological and psychiatric therapeutics, making this intermediate relevant for CNS-targeted drug development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and niche APIs.
• Chemical Biology Probes: Utilized in the creation of chemical probes for studying biological pathways and target validation.

Basic Information

Item	Detail
Product Name	tert-Butyl 4-[3-Bromo-5-(Methoxycarbonyl)Pyridin-2-Yl]Piperazine-1-Carboxylate
CAS No.	906559-32-8
Molecular Formula	C16H20BrN3O4
Molecular Weight	398.25 g/mol
Synonyms	1-Boc-4-(3-Bromo-5-(methoxycarbonyl)pyridin-2-yl)piperazine; tert-Butyl 4-(3-bromo-5-(methoxycarbonyl)pyridin-2-yl)piperazine-1-carboxylate; 2-(1-Boc-piperazin-4-yl)-3-bromo-5-methoxycarbonylpyridine; 906559-32-8; 1-(tert-Butoxycarbonyl)-4-[3-bromo-5-(methoxycarbonyl)-2-pyridyl]piperazine; Boc-piperazine-pyridine-bromo-ester intermediate
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-[3-Bromo-5-(Methoxycarbonyl)Pyridin-2-Yl]Piperazine-1-Carboxylate adheres to stringent quality management systems, ensuring batch-to-batch consistency suitable for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with ISO and cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.