Description

5-(Chloromethyl)-2-(Tetrahydro-2H-Pyran-4-Yloxy)Pyridine 97% is a high-purity, advanced pharmaceutical intermediate featuring a reactive chloromethyl group and a protected pyranyloxy moiety. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapeutics. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in novel drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially kinase inhibitors and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its versatile reactive sites for further functionalization.
• Process Development: Serves as a critical starting material or intermediate in scaling up API manufacturing processes under GMP conditions.
• Bioconjugation & Probe Synthesis: The chloromethyl group can be utilized for attaching fluorescent tags, affinity labels, or other molecular probes for biochemical research.
• Agrochemical Intermediate: Potential use in the synthesis of novel crop protection agents and pesticides.

Basic Information

Product Name	5-(Chloromethyl)-2-(Tetrahydro-2H-Pyran-4-Yloxy)Pyridine 97%
CAS No.	906352-80-5
Molecular Formula	C11H14ClNO2
Molecular Weight	227.69 g/mol
Synonyms	2-((Tetrahydro-2H-pyran-4-yl)oxy)-5-(chloromethyl)pyridine; 5-(Chloromethyl)-2-(tetrahydropyran-4-yloxy)pyridine; 2-(Oxan-4-yloxy)-5-(chloromethyl)pyridine; 906352-80-5; THP-protected chloromethylpyridine derivative; 5-Chloromethyl-2-(tetrahydro-2H-pyran-4-yloxy)pyridine
EINECS	Contact for details

Quality Control

Our 5-(Chloromethyl)-2-(Tetrahydro-2H-Pyran-4-Yloxy)Pyridine 97% is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.