Description

Pentafluorophenyl 2-Pyrid-3-Yl-1,3-Thiazole-4-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound matters because it combines a reactive pentafluorophenyl ester group with a pyridyl-thiazole pharmacophore, enabling efficient derivatization for creating complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, chemical biology, and materials science.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Chemical Biology Probe Development: Used to create affinity-based probes for target identification and protein profiling studies due to its reactive ester handle.
• Agrochemical Research: Acts as a building block for developing new crop protection agents with potential insecticidal or fungicidal activity.
• Material Science: Employed in the synthesis of organic semiconductors or liquid crystals, where the fluorinated aromatic system can modulate electronic properties.
• Peptide & Protein Conjugation: The pentafluorophenyl ester is highly reactive towards amines, making it useful for bioconjugation and labeling applications.
• Library Synthesis for Drug Discovery: A versatile scaffold for generating diverse compound libraries via high-throughput synthesis for screening campaigns.

Basic Information

Product Name	Pentafluorophenyl 2-Pyrid-3-Yl-1,3-Thiazole-4-Carboxylate
CAS No.	906352-58-7
Molecular Formula	C16H6F5N2O2S
Molecular Weight	385.29 g/mol
Synonyms	2-(Pyridin-3-yl)-1,3-thiazole-4-carboxylic acid pentafluorophenyl ester; Pentafluorophenyl 2-(3-pyridyl)-1,3-thiazole-4-carboxylate; 4-Carboxy-2-(3-pyridyl)thiazole pentafluorophenyl ester; 2-(3-Pyridinyl)-4-thiazolecarboxylic acid 2,3,4,5,6-pentafluorophenyl ester; PFP-ester of 2-(3-pyridyl)thiazole-4-carboxylic acid; 906352-58-7; Pentafluorophenyl 2-(pyridin-3-yl)thiazole-4-carboxylate
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl 2-Pyrid-3-Yl-1,3-Thiazole-4-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, NMR, and MS for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged manipulations to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.