Description

5-Bromo-3-((trimethylsilyl)ethynyl)pyridin-2-amine is a high-value pyridine derivative featuring both bromo and trimethylsilyl-protected ethynyl functional groups, making it a versatile and reactive synthetic intermediate. This compound is essential for advanced organic synthesis, particularly in the construction of complex heterocyclic scaffolds and functionalized molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides with tailored biological activity.
• Material Science: Serves as a precursor for functionalized polymers, ligands for catalysis, and organic electronic materials.
• Cross-Coupling Reactions: The bromo and ethynyl groups make it an excellent substrate for Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology: Employed in the synthesis of molecular probes and bioconjugates for target identification and validation studies.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory chemistry in academic and CRO laboratories.

Basic Information

Product Name	5-Bromo-3-((trimethylsilyl)ethynyl)pyridin-2-amine
CAS No.	905966-34-9
Molecular Formula	C10H13BrN2Si
Molecular Weight	269.22 g/mol
Synonyms	2-Amino-5-bromo-3-[(trimethylsilyl)ethynyl]pyridine; 5-Bromo-3-((trimethylsilyl)ethynyl)-2-pyridinamine; 5-Bromo-3-[(trimethylsilyl)ethynyl]pyridin-2-amine; 2-Pyridinamine, 5-bromo-3-[(trimethylsilyl)ethynyl]-; 5-Bromo-3-(2-trimethylsilylethynyl)pyridin-2-amine; 5-Bromo-3-(trimethylsilylethynyl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-((trimethylsilyl)ethynyl)pyridin-2-amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.