Description

5-Fluoro-2-[[(1S)-1-(4-Fluorophenyl)Ethyl]Amino]-6-[(5-Methyl-1H-Pyrazol-3-Yl)Amino]-3-Pyridinecarbonitrile is a high-purity, chiral organic compound of significant interest in advanced pharmaceutical research and development. Its complex molecular architecture, featuring multiple heterocyclic and fluorinated motifs, makes it a critical intermediate for synthesizing novel, targeted therapeutic agents. This compound is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the discovery of new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors and other targeted small-molecule therapeutics.
• Preclinical Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Biology Probe: Serves as a core structure for developing tool compounds to study specific biological pathways and protein functions.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Custom Synthesis: A starting material for contract research organizations (CROs) providing bespoke chemical synthesis services to the biopharma industry.

Basic Information

Item	Details
Product Name	5-Fluoro-2-[[(1S)-1-(4-Fluorophenyl)Ethyl]Amino]-6-[(5-Methyl-1H-Pyrazol-3-Yl)Amino]-3-Pyridinecarbonitrile
CAS No.	905586-69-8
Molecular Formula	C19H17F2N7
Molecular Weight	381.38 g/mol
Synonyms	5-Fluoro-2-(((1S)-1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile; (S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile; 905586-69-8; UNII-6Y6N8U8Q8F; 6Y6N8U8Q8F; CHEMBL3186669; AKOS015915896; BDBM50111371
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Quality is verified through comprehensive analytical methods including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.